The role of klotho in systemic sclerosis.
Identifieur interne : 000C89 ( Main/Exploration ); précédent : 000C88; suivant : 000C90The role of klotho in systemic sclerosis.
Auteurs : R. Talotta [Italie] ; S. Bongiovanni ; T. Letizia ; F. Rigamonti ; F. Atzeni ; M. Benucci ; T. Vago ; P. Sarzi-PuttiniSource :
- Reumatismo [ 0048-7449 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Angioscopie microscopique, Femelle, Glucuronidase (physiologie), Glucuronidase (sang), Humains, Immunosuppresseurs (usage thérapeutique), Marqueurs biologiques, Mâle, Ostéoporose (étiologie), Poumon (anatomopathologie), Prostaglandines (usage thérapeutique), Sclérodermie systémique (), Sclérodermie systémique (anatomopathologie), Sclérodermie systémique (sang), Sclérodermie systémique (traitement médicamenteux), Statistique non paramétrique, Sujet âgé.
- MESH :
- anatomopathologie : Poumon, Sclérodermie systémique.
- physiologie : Glucuronidase.
- sang : Glucuronidase, Sclérodermie systémique.
- traitement médicamenteux : Sclérodermie systémique.
- usage thérapeutique : Immunosuppresseurs, Prostaglandines.
- étiologie : Ostéoporose.
- Adulte, Adulte d'âge moyen, Angioscopie microscopique, Femelle, Humains, Marqueurs biologiques, Mâle, Sclérodermie systémique, Statistique non paramétrique, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers, Female, Glucuronidase (blood), Glucuronidase (physiology), Humans, Immunosuppressive Agents (therapeutic use), Lung (pathology), Male, Microscopic Angioscopy, Middle Aged, Osteoporosis (etiology), Prostaglandins (therapeutic use), Scleroderma, Systemic (blood), Scleroderma, Systemic (complications), Scleroderma, Systemic (drug therapy), Scleroderma, Systemic (pathology), Statistics, Nonparametric.
- MESH :
- chemical , blood : Glucuronidase.
- chemical , physiology : Glucuronidase.
- chemical , therapeutic use : Immunosuppressive Agents, Prostaglandins.
- chemical : Biomarkers.
- blood : Scleroderma, Systemic.
- complications : Scleroderma, Systemic.
- drug therapy : Scleroderma, Systemic.
- etiology : Osteoporosis.
- pathology : Lung, Scleroderma, Systemic.
- Adult, Aged, Female, Humans, Male, Microscopic Angioscopy, Middle Aged, Statistics, Nonparametric.
Abstract
The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan's Skin Score, Medsger's scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p<0.001). However, Spearman's test showed no significant association between klotho serum levels and disease activity, concerning either clinical, laboratory or instrumental findings. Our data show a significant deficit of klotho in SSc patients although any significant association was detected between klotho serum concentration and the clinical, laboratory or instrumental features of the disease. However, due to the limits of the study, further investigations are required.
DOI: 10.4081/reumatismo.2017.987
PubMed: 29320841
Affiliations:
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Talotta</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, Luigi Sacco University-Hospital, Milan. talotta1@virgilio.it.</nlm:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Department of Rheumatology, Luigi Sacco University-Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Bongiovanni, S" sort="Bongiovanni, S" uniqKey="Bongiovanni S" first="S" last="Bongiovanni">S. Bongiovanni</name></author><author><name sortKey="Letizia, T" sort="Letizia, T" uniqKey="Letizia T" first="T" last="Letizia">T. Letizia</name></author><author><name sortKey="Rigamonti, F" sort="Rigamonti, F" uniqKey="Rigamonti F" first="F" last="Rigamonti">F. Rigamonti</name></author><author><name sortKey="Atzeni, F" sort="Atzeni, F" uniqKey="Atzeni F" first="F" last="Atzeni">F. Atzeni</name></author><author><name sortKey="Benucci, M" sort="Benucci, M" uniqKey="Benucci M" first="M" last="Benucci">M. Benucci</name></author><author><name sortKey="Vago, T" sort="Vago, T" uniqKey="Vago T" first="T" last="Vago">T. Vago</name></author><author><name sortKey="Sarzi Puttini, P" sort="Sarzi Puttini, P" uniqKey="Sarzi Puttini P" first="P" last="Sarzi-Puttini">P. Sarzi-Puttini</name></author></analytic><series><title level="j">Reumatismo</title><idno type="ISSN">0048-7449</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers</term><term>Female</term><term>Glucuronidase (blood)</term><term>Glucuronidase (physiology)</term><term>Humans</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Lung (pathology)</term><term>Male</term><term>Microscopic Angioscopy</term><term>Middle Aged</term><term>Osteoporosis (etiology)</term><term>Prostaglandins (therapeutic use)</term><term>Scleroderma, Systemic (blood)</term><term>Scleroderma, Systemic (complications)</term><term>Scleroderma, Systemic (drug therapy)</term><term>Scleroderma, Systemic (pathology)</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angioscopie microscopique</term><term>Femelle</term><term>Glucuronidase (physiologie)</term><term>Glucuronidase (sang)</term><term>Humains</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Ostéoporose (étiologie)</term><term>Poumon (anatomopathologie)</term><term>Prostaglandines (usage thérapeutique)</term><term>Sclérodermie systémique ()</term><term>Sclérodermie systémique (anatomopathologie)</term><term>Sclérodermie systémique (sang)</term><term>Sclérodermie systémique (traitement médicamenteux)</term><term>Statistique non paramétrique</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glucuronidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Glucuronidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term><term>Prostaglandins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Sclérodermie systémique</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Osteoporosis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Scleroderma, Systemic</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Glucuronidase</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Glucuronidase</term><term>Sclérodermie systémique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sclérodermie systémique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term><term>Prostaglandines</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Ostéoporose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Microscopic Angioscopy</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angioscopie microscopique</term><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Sclérodermie systémique</term><term>Statistique non paramétrique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan's Skin Score, Medsger's scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p<0.001). However, Spearman's test showed no significant association between klotho serum levels and disease activity, concerning either clinical, laboratory or instrumental findings. Our data show a significant deficit of klotho in SSc patients although any significant association was detected between klotho serum concentration and the clinical, laboratory or instrumental features of the disease. However, due to the limits of the study, further investigations are required.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Atzeni, F" sort="Atzeni, F" uniqKey="Atzeni F" first="F" last="Atzeni">F. Atzeni</name><name sortKey="Benucci, M" sort="Benucci, M" uniqKey="Benucci M" first="M" last="Benucci">M. Benucci</name><name sortKey="Bongiovanni, S" sort="Bongiovanni, S" uniqKey="Bongiovanni S" first="S" last="Bongiovanni">S. Bongiovanni</name><name sortKey="Letizia, T" sort="Letizia, T" uniqKey="Letizia T" first="T" last="Letizia">T. Letizia</name><name sortKey="Rigamonti, F" sort="Rigamonti, F" uniqKey="Rigamonti F" first="F" last="Rigamonti">F. Rigamonti</name><name sortKey="Sarzi Puttini, P" sort="Sarzi Puttini, P" uniqKey="Sarzi Puttini P" first="P" last="Sarzi-Puttini">P. Sarzi-Puttini</name><name sortKey="Vago, T" sort="Vago, T" uniqKey="Vago T" first="T" last="Vago">T. Vago</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Talotta, R" sort="Talotta, R" uniqKey="Talotta R" first="R" last="Talotta">R. Talotta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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